VX-222

Name: VX-222
Brand: Adooq Bioscience
SKU: A10980
Rating: 100 (2 reviews)

Catalog No.: A10980

HCV Protease inhibitor

Product Citations (2)

VX-222 Chemical Structure

CAS NO. 1026785-59-0

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$450.00
100 mg	$750.00
10mM * 1mL in DMSO	$139.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq VX-222

Wataru Ito, .et al. Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative, Antivir Chem Chemother, 2015, Dec; 24(5-6): 148-154 PMID: 27503576
Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Biological Activity

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

Targets

HCV NS5B 1a	HCV NS5B 1b
0.94 μM	1.2 μM

Solubility *

In vitro (25°C)	DMSO	76 mg/mL (170.55 mM)
	Water	Insoluble
	Ethanol	76 mg/mL (170.55 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.44 mL	112.21 mL	224.42 mL
0.5 mM	4.49 mL	22.44 mL	44.88 mL
1 mM	2.24 mL	11.22 mL	22.44 mL
5 mM	0.45 mL	2.24 mL	4.49 mL

*The above data is based on the productmolecular weight 445.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10980
Actions	Inhibitor
CAS No.	1026785-59-0
Formula	C25H35NO4S
M. Wt	445.6
Purity	>98%
Synonyms	VCH222, VX222
SMILES	CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.