VX-222

Catalog No.: A10980

HCV Protease inhibitor

VX-222

VX-222 Chemical Structure

CAS NO. 1026785-59-0

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
10mM * 1mL in DMSO
$139.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Wataru Ito, .et al. Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative, Antivir Chem Chemother, 2015, Dec; 24(5-6): 148-154 PMID: 27503576
  • Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Biological Activity

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
Targets
HCV NS5B 1a HCV NS5B 1b
0.94 μM1.2 μM
In vitro (25°C) DMSO 76 mg/mL (170.55 mM)
Water Insoluble
Ethanol 76 mg/mL (170.55 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.44 mL 112.21 mL 224.42 mL
0.5 mM 4.49 mL 22.44 mL 44.88 mL
1 mM 2.24 mL 11.22 mL 22.44 mL
5 mM 0.45 mL 2.24 mL 4.49 mL

*The above data is based on the productmolecular weight 445.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10980
Actions Inhibitor
CAS No. 1026785-59-0
Formula C25H35NO4S
M. Wt 445.6
Purity >98%
Synonyms VCH222, VX222
SMILES CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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