VX-222

Name: VX-222
SKU: A10980

Catalog No.: A10980

HCV Protease inhibitor

Product Citations (2)

VX-222

VX-222 Chemical Structure

CAS NO. 1026785-59-0

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$450.00
100 mg	$750.00
10mM * 1mL in DMSO	$139.00

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Adooq Products cited in reputable papers

Biological Activity

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

Targets

HCV NS5B 1a	HCV NS5B 1b
0.94 μM	1.2 μM

Solubility *

In vitro (25°C)	DMSO	89 mg/mL (199.72 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	89 mg/mL (199.72 mM)
In vivo	30% PEG400/0.5% Tween80/5% propylene glycol	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.44 mL	112.21 mL	224.42 mL
0.5 mM	4.49 mL	22.44 mL	44.88 mL
1 mM	2.24 mL	11.22 mL	22.44 mL
5 mM	0.45 mL	2.24 mL	4.49 mL

*The above data is based on the productmolecular weight 445.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10980
Actions	Inhibitor
M. Wt	445.6
Formula	C25H35NO4S
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1026785-59-0
Synonyms	VCH222, VX222
SMILES	CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O