Catalog No.: A11186
FXR agonist

WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

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Product Name Price Stock Qty
WAY-362450 5mg
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WAY-362450 10mg
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WAY-362450 50mg
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WAY-362450 100mg
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WAY-362450 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's WAY-362450 has been cited by 2 publications
  • Dong-Hyun Kim, .et al. , Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
  • Dong-Hyun Kim, .et al. , FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
  • Biological Activity

    WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

    Target Value
    Product Information
    Catalog Num A11186
    Formula C25H24F2N2O3
    Molecular Weight 438.47
    CAS Number 629664-81-9
    SMILES CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F
    Synonyms WAY362450, XL335

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO Warmed: 31 mg/mL (70.7 mM)
    Water Insoluble
    Ethanol 2 mg/mL (4.56 mM)
    In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.81 mL 114.03 mL 228.07 mL
    0.5 mM 4.56 mL 22.81 mL 45.61 mL
    1 mM 2.28 mL 11.4 mL 22.81 mL
    5 mM 0.46 mL 2.28 mL 4.56 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
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