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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
Biological Activity
WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).
Targets
| FXR | ||||
| 4 nM(EC50) |
| In vitro (25°C) | DMSO | Warmed: 31 mg/mL (70.7 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (4.56 mM) | ||
| In vivo | NMP+PEG300 (10+90, v+v) | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.81 mL | 114.03 mL | 228.07 mL |
| 0.5 mM | 4.56 mL | 22.81 mL | 45.61 mL |
| 1 mM | 2.28 mL | 11.4 mL | 22.81 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11186 |
|---|---|
| Actions | Agonist |
| CAS No. | 629664-81-9 |
| Formula | C25H24F2N2O3 |
| M. Wt | 438.47 |
| Purity | >98% |
| Synonyms | WAY362450, XL335 |
| SMILES | CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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