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Catalog No.: A11186

FXR agonist


WAY-362450 Chemical Structure

CAS NO. 629664-81-9

WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

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5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $150.00

Special Price $120.00

50 mg

Regular Price: $480.00

Special Price $384.00

100 mg

Regular Price: $780.00

Special Price $624.00

10mM * 1mL in DMSO

Regular Price: $100.00

Special Price $80.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
  • Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930

Biological Activity

WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

4 nM(EC50)
In vitro (25°C) DMSO Warmed: 31 mg/mL (70.7 mM)
Water Insoluble
Ethanol 2 mg/mL (4.56 mM)
In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.03 mL 228.07 mL
0.5 mM 4.56 mL 22.81 mL 45.61 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11186
Actions Agonist
CAS No. 629664-81-9
Formula C25H24F2N2O3
M. Wt 438.47
Purity >98%
Synonyms WAY362450, XL335

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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