WP1130 (Degrasyn)

Catalog No.: A10988
DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
Grouped product items
Size Price Stock Qty
5mg
$50.00
In stock
10mg
$95.00
In stock
25mg
$200.00
In stock
50mg
$275.00
In stock
100mg
$445.00
In stock
10mM * 1mL in DMSO
$55.00
In stock
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Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's WP1130 (Degrasyn) has been cited by 1 publications
  • Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
  • Biological Activity
    Discription WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A10988
    Formula C19H18BrN3O
    Molecular Weight 384.3
    CAS Number 856243-80-6
    SMILES CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
    Synonyms WP-1130, Degrasyn
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 73 mg/mL (189.96 mM)
    Water Insoluble
    Ethanol 17 mg/mL (44.24 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.02 mL 130.11 mL 260.21 mL
    0.5 mM 5.2 mL 26.02 mL 52.04 mL
    1 mM 2.6 mL 13.01 mL 26.02 mL
    5 mM 0.52 mL 2.6 mL 5.2 mL
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