WP1130 (Degrasyn)

Catalog No.: A10988

DUB/Bcr/ABL Inhibitor

WP1130 (Degrasyn)

WP1130 (Degrasyn) Chemical Structure

CAS NO. 856243-80-6

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
50 mg
$280.00
100 mg
$450.00
10mM * 1mL in DMSO
$105.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
Targets
DUB (Cell-free assay) Bcr-Abl (Cell-free assay)
N/A1.8 μM
In vitro DMSO 77 mg/mL (200.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (46.84 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.02 mL 130.11 mL 260.21 mL
0.5 mM 5.2 mL 26.02 mL 52.04 mL
1 mM 2.6 mL 13.01 mL 26.02 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10988
Actions Inhibitor
M. Wt 384.3
Formula C19H18BrN3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 856243-80-6
Synonyms WP-1130, Degrasyn
SMILES CCC[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

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