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Biological Activity
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
Targets
| DUB (Cell-free assay) | Bcr-Abl (Cell-free assay) | |||
| N/A | 1.8 μM |
| In vitro | DMSO | 73 mg/mL (189.96 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (44.24 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.02 mL | 130.11 mL | 260.21 mL |
| 0.5 mM | 5.2 mL | 26.02 mL | 52.04 mL |
| 1 mM | 2.6 mL | 13.01 mL | 26.02 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
*The above data is based on the productmolecular weight 384.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10988 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 856243-80-6 |
| Formula | C19H18BrN3O |
| M. Wt | 384.3 |
| Purity | >98% |
| Synonyms | WP-1130, Degrasyn |
| SMILES | CCC[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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