WYE-125132 (WYE-132)

Catalog No.: A11038

mTOR Inhibitor

WYE-125132 (WYE-132) Chemical Structure

CAS NO. 1144068-46-1

WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
50 mg
$720.00
100 mg
$1,200.00
10mM * 1mL in DMSO
$135.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).
Targets
mTOR
0.19 nM
In vitro (25°C) DMSO 104 mg/mL (200.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11038
Actions Inhibitor
M. Wt 519.6
Formula C27H33N7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1144068-46-1
Synonyms WYE125132, WYE-132, WYE132
SMILES CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7

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