WYE-125132 (WYE-132)

Catalog No.: A11038

mTOR Inhibitor

WYE-125132 (WYE-132)

WYE-125132 (WYE-132) Chemical Structure

CAS NO. 1144068-46-1

WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).

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5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $720.00

Special Price $576.00

100 mg

Regular Price: $1,200.00

Special Price $960.00

10mM * 1mL in DMSO

Regular Price: $135.00

Special Price $108.00

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Biological Activity

WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).
Targets
mTOR
0.19 nM
In vitro (25°C) DMSO 95 mg/mL (182.83 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11038
Actions Inhibitor
CAS No. 1144068-46-1
Formula C27H33N7O4
M. Wt 519.6
Purity >98%
Synonyms WYE125132, WYE-132, WYE132
SMILES CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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