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- Krishna Chintaluri, .et al. The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells, PLoS One, 2018, 13(6): e0198454 PMID: 29870544
- Dayam RM, .et al. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase, J Immunol, 2017, Sep 15;199(6):2096-2105 PMID: 28779020
Biological Activity
YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).
Targets
| PIKfyve | p110α | |||
| 33 nM | 3.3 μM |
| In vitro | DMSO | 31 mg/mL (66.3 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.39 mL | 106.95 mL | 213.9 mL |
| 0.5 mM | 4.28 mL | 21.39 mL | 42.78 mL |
| 1 mM | 2.14 mL | 10.7 mL | 21.39 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
*The above data is based on the productmolecular weight 467.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11064 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 371942-69-7 |
| Formula | C25H21N7O3 |
| M. Wt | 467.5 |
| Purity | >98% |
| Synonyms | YM-201636 |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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YM201636
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