Zibotentan (ZD4054)

Catalog No.: A11006

ETA-receptor Antagonist

Zibotentan (ZD4054) Chemical Structure

CAS NO. 186497-07-4

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
10mM * 1mL in DMSO
$135.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
Targets
ET-A
21 nM
In vitro (25°C) DMSO 24 mg/mL (56.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.56 mL 117.81 mL 235.63 mL
0.5 mM 4.71 mL 23.56 mL 47.13 mL
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL

*The above data is based on the productmolecular weight 424.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11006
Actions Antagonist
M. Wt 424.4
Formula C19H16N6O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 186497-07-4
Synonyms ZD-4054
SMILES CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

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