Aprepitant (MK-0869)
Catalog No. A10083
Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.
Catalog Num | A10083 |
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M. Wt | 534.4 |
Formula | C23H21F7N4O3 |
Purity | >98% |
Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
CAS No. | 170729-80-3 |
Synonyms | L-754030, Emend |
SMILES | C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Discription | Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy. |
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Targets |
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In vitro (25°C) | DMSO | 96 mg/mL (179.63 mM) | |
Water | Insoluble | ||
Ethanol | 14 mg/mL (26.19 mM) | ||
In vivo | 5% DMSO+corn oil | 12 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 18.71 mL | 93.56 mL | 187.13 mL |
0.5 mM | 3.74 mL | 18.71 mL | 37.43 mL |
1 mM | 1.87 mL | 9.36 mL | 18.71 mL |
5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
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