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Catalog No. Product Name Application Information
A17216
BAY-876
GLUT1 Inhibitor
BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in vitro and high oral bioavailability in vivo.
A17227
AG1295
PDGFR inhibitor
AG1295 is a PDGF receptor specific inhibitor.
A17230
BIBF0775
TGFβRI inhibitor
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI).
A17228
MDL-800
SIRT6 allosteric activator
MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.
A17221
PF-06371900
LRRK2 inhibitor
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor.
A17223
MRTX1257
KRAS-G12C inhibitor
MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
A17240
Incyclinide
MMP inhibitor
Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
A17235
SBI-115
GPCR19 antagonist
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
A17226
Mivebresib (ABBV-075)
BET inhibitor
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity.
A17218
MX1013
pan-caspase inhibitor
MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9.
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