Product Data Sheet

CHIR-99021

Catalog No. A10199

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CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
Adooq's CHIR-99021 has been cited by 9 publications
  • Eric Lian, .et al. , STAR Protoc, 2023, May 22;4(2):102314 PMID: 37220001
  • Tomoki Murata, .et al. , Int Immunol, 2023, Apr 13 PMID: 37052267
  • Shunsuke Murakami, .et al. , Regen Ther, 2022, Nov 25;21:574-583 PMID: 36475025
  • Adam Pietrobon, .et al. , Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
  • Takayuki Miyoshi, .et al. , J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
  • Tomoki Kamatani, .et al. , Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370
  • Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
  • Otsuka R, .et al. , Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817
  • Yu Huang, .et al. , Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
    • Chemical Information
    Catalog Num A10199
    M. Wt 465.3
    Formula C22H18Cl2N8
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 252917-06-9
    Synonyms GSK-3 Inhibitor XVI, CT 99021
    SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Warmed: 9 mg/mL (19.33 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+ddH2O 3.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.49 mL 107.46 mL 214.92 mL
    0.5 mM 4.3 mL 21.49 mL 42.98 mL
    1 mM 2.15 mL 10.75 mL 21.49 mL
    5 mM 0.43 mL 2.15 mL 4.3 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.