Product Data Sheet

CK-1827452 (Omecamtiv mecarbil)

Catalog No. A11206

main product photo
CK-1827452 is a selective cardiac specific myosin activator.
Adooq's CK-1827452 (Omecamtiv mecarbil) has been cited by 11 publications
  • Oleg Lookin, .et al. , Clin Exp Pharmacol Physiol, 2021, Aug 29 PMID: 34459025
  • Gabor A. Fulop, .et al. , Basic Res Cardiol, 2021, 116(1): 24 PMID: 33844095
  • Wanjian Tang, .et al. , J Biol Chem, 2019, October 2 PMID: 31578282
  • Thinh T. Kieu, .et al. , Biophysical Journal, 2019, 2019 PMID: 31103235
  • Alexandre J. S. Ribeiro, .et al. , Circ Res, 2017, May 12; 120(10): 1572-1583 PMID: 28400398
  • Anja M. Swenson, .et al. , J Biol Chem, 2017, Mar 3; 292(9): 3768-3778 PMID: 28082673
  • Nánási P Jr, .et al. , Eur J Pharmacol, 2017, Aug 15;809:73-79 PMID: 28506910
  • Horváth B, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 PMID: 28940010
  • Szentandrassy N, .et al. , J Physiol Pharmacol, 2016, Aug;67(4):483-489 PMID: 27779469
  • L Nagy, .et al. , Br J Pharmacol, 2015, Sep; 172(18): 4506-4518 PMID: 26140433
  • Larissa Butler, .et al. , Toxicol Sci, 2015, Jun;145(2):396-406 PMID: 25820236
    • Chemical Information
    Catalog Num A11206
    M. Wt 401.43
    Formula C20H24FN5O3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 873697-71-3
    Synonyms CK1827452, Omecamtiv Mecarbil
    SMILES CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription CK-1827452 is a selective cardiac specific myosin activator.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 73 mg/mL (181.84 mM)
    Water Insoluble
    Ethanol 5 mg/mL (12.45 mM)
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.91 mL 124.55 mL 249.11 mL
    0.5 mM 4.98 mL 24.91 mL 49.82 mL
    1 mM 2.49 mL 12.46 mL 24.91 mL
    5 mM 0.5 mL 2.49 mL 4.98 mL
    RETURN POLICY
    Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.