Product Data Sheet

(+)-JQ1

Catalog No. A12729

main product photo
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
Adooq's (+)-JQ1 has been cited by 10 publications
  • Adriana K Alexander, .et al. , Nat Commun, 2023, Mar 29;14(1):1753 PMID: 36990976
  • Haruki Kitamura, .et al. , Biochem Biophys Res Commun, 2023, Jan 22;641:139-147 PMID: 36527748
  • Gerald Thiel, .et al. , Pharmaceuticals (Basel), 2022, Jul 10;15(7):846 PMID: 35890145
  • Selase D Deletsu, .et al. , Biochem Biophys Res Commun, 2021, Aug 27;567:106-111 PMID: 34146904
  • Cole Schonhofer, .et al. , Biochem Pharmacol, 2021, Apr;186:114462 PMID: 33577894
  • Nandini Verma, .et al. , Sci Adv, 2020, 6 : eaba8968
  • Kuo MT, .et al. , Transl Oncol, 2020, 13(2):355-364 PMID: 31887630
  • Rao Z, .et al. , J Immunol, 2019, Aug 15;203(4):1031-1043 PMID: 31300512
  • A Carrer, .et al. , Cancer Discov, 2019, Jan 9. pii: CD-18-0567 PMID: 30626590
  • Clocchiatti A, .et al. , J Clin Invest, 2018, Dec 3;128(12):5531-5548 PMID: 30395538
    • Chemical Information
    Catalog Num A12729
    M. Wt 456.99
    Formula C23H25ClN4O2S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1268524-70-4
    Synonyms
    SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
    Solubility
    In vitro (25°C) DMSO Warmed: 90 mg/mL (196.93 mM)
    Water Insoluble
    Ethanol 90 mg/mL
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.88 mL 109.41 mL 218.82 mL
    0.5 mM 4.38 mL 21.88 mL 43.76 mL
    1 mM 2.19 mL 10.94 mL 21.88 mL
    5 mM 0.44 mL 2.19 mL 4.38 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.