Product Data Sheet

LY2835219 methanesulfonate

Catalog No. A16386

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LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
Adooq's LY2835219 methanesulfonate has been cited by 1 publications
  • Shuso Takeda, .et al. , Fundam Toxicol Sci, 2021, 8(3):75-80
    • Chemical Information
    Catalog Num A16386
    M. Wt 602.7
    Formula C27H32F2N8.CH4O3S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1231930-82-7
    Synonyms Abemaciclib
    SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 81 mg/mL (134.39 mM)
    Water 97 mg/mL (160.94 mM)
    Ethanol 23 mg/mL
    In vivo water 95 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.59 mL 82.96 mL 165.92 mL
    0.5 mM 3.32 mL 16.59 mL 33.18 mL
    1 mM 1.66 mL 8.3 mL 16.59 mL
    5 mM 0.33 mL 1.66 mL 3.32 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.