Product Data Sheet

Sorafenib Tosylate (Nexavar)

Catalog No. A10001

main product photo
Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
Adooq's Sorafenib Tosylate (Nexavar) has been cited by 12 publications
  • Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
  • Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Jindal A, .et al. , J Transl Sci, 2020, 7: 1-10
  • Mariko Fujisawa, .et al. , Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
  • Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298
  • Fangyuan Lai, .et al. , Stem Cell Res Ther, 2018, 9: 107 PMID: 29661222
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Arum Park, .et al. , J Cancer, 2017, 8(12): 2303-2311 PMID: 28819434
  • Cong Li, .et al. , Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Zhihong Li, .et al. , J Med Chem, 2014, Apr 24;57(8):3430-49 PMID: 24641103
  • Hideki Yamaguchi, .et al. , Cancer Sci, 2014, 105(5): 528-536 PMID: 24612061
  • Yaping Zhang, .et al. , J Pharmacokinet Pharmacodyn., 2014, 41(6): 675-691 PMID: 25326874
    • Chemical Information
    Catalog Num A10001
    M. Wt 637
    Formula C21H16ClF3N4O3.C7H8O3S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 475207-59-1
    Synonyms Bay 43-9006
    SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 114 mg/mL (178.95 mM)
    Water <1 mg/mL
    Ethanol Insoluble
    In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 15.7 mL 78.49 mL 156.99 mL
    0.5 mM 3.14 mL 15.7 mL 31.4 mL
    1 mM 1.57 mL 7.85 mL 15.7 mL
    5 mM 0.31 mL 1.57 mL 3.14 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.