Product Data Sheet

Olaparib (AZD2281)

Catalog No. A10111

main product photo
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
Adooq's Olaparib (AZD2281) has been cited by 28 publications
  • Saptarshi Sinha, .et al. , Exp Cell Res, 2022, Nov 1;420(1):113338 PMID: 36075449
  • Subhajit Chatterjee, .et al. , J Cancer Res Clin Oncol, 2022, Dec;148(12):3521-3535 PMID: 35962813
  • Yuki Uchihara, .et al. , Mol Cell, 2022, Jul 21;82(14):2557-2570 PMID: 35594857
  • Ji-Ye Kim, .et al. , Cell Death Dis, 2022, Mar 15;13(3):239 PMID: 35293383
  • Emad Matanes, .et al. , Front Oncol, 2021, Oct 27;11:745981 PMID: 34778062
  • Shino Endo, .et al. , Cancer Res Commun, 2021, 1(2): 90-105
  • Yan Baglo, .et al. , Transl Oncol, 2021, Nov;14(11):101198 PMID: 34418731
  • Joseph M Gozgit, .et al. , Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
  • Sefinew Molla, .et al. , DNA Repair (Amst), 2021, Jun 10;105:103157 PMID: 34144488
  • Jianming Wang, .et al. , Cell Rep, 2021, Feb 16;34(7):108759 PMID: 33596418
  • Ai Ito, .et al. , Biogerontology, 2021, Feb;22(1):119-131 PMID: 33216250
  • Tim J Wigle, .et al. , Cell Chem Biol, 2020, Jul 16;27(7):877-887 PMID: 32679093
  • Ali Divan, .et al. , Pharmacol Res Perspect, 2020, Apr; 8(2): e00586 PMID: 32342655
  • Jianwei Dou, .et al. , J Sep Sci, 2020, Dec 4 PMID: 33275824
  • Sai Dimple Manavitha Gullipalli, .et al. , Int. J. Adv. Pharm. Biotech, 2020, 6(2) 01-08
  • Chao Zhang, .et al. , J Atheroscler Thromb, 2020, Sep 25 PMID: 32981917
  • Wigle TJ, .et al. , SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
  • Wang Q, .et al. , Cancer Med, 2019, Dec 21 PMID: 31863638
  • Molla S, .et al. , Pathol Oncol Res, 2019, Nov 25 PMID: 31768967
  • Alvin Z.Lu, .et al. , Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
  • Bian C, .et al. , Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
  • HC de Silva, .et al. , Cell Mol Life Sci, 2019, 1-16 PMID: 30725116
  • Kamada Y, .et al. , Fitoterapia, 2018, Sep;129:94-101 PMID: 29928967
  • 2018, .et al. , FEBS Open Bio, 2018, Jun; 8(6): 1001-1012 PMID: 29928579
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Hiro Sato, .et al. , Nat Commun, 2017, 8: 1751 PMID: 29170499
  • Charles-André Philip, .et al. , BMC Cancer, 2017, 17: 638 PMID: 28886696
  • Rulina AV, .et al. , Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189
    • Chemical Information
    Catalog Num A10111
    M. Wt 434.5
    Formula C24H23FN4O3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 763113-22-0
    Synonyms KU-0059436
    SMILES C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Warmed: 74 mg/mL (170.32 mM)
    Water <1 mg/mL
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.01 mL 115.07 mL 230.15 mL
    0.5 mM 4.6 mL 23.01 mL 46.03 mL
    1 mM 2.3 mL 11.51 mL 23.01 mL
    5 mM 0.46 mL 2.3 mL 4.6 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.