Product Data Sheet

Bafetinib (INNO-406)

Catalog No. A10119

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Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.
Adooq's Bafetinib (INNO-406) has been cited by 5 publications
  • Yusuke Kimata, .et al. , Life Sci Alliance, 2023, Feb 27;6(5):e202201657 PMID: 36849250
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • S. Dallari, .et al. , Nat Commun, 2017, 8: 14830 PMID: 28368000
  • Andrea Haerzschel, .et al. , Ann Hematol, 2016, 95(12): 1979-1988 PMID: 27542958
  • Magdalena Winiarska, .et al. , MAbs., 2014, 6(5): 1300-1313 PMID: 25517315
    • Chemical Information
    Catalog Num A10119
    M. Wt 576.6
    Formula C30H31F3N8O
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 859212-16-1
    Synonyms NS-187
    SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[C@@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 92 mg/mL (159.55 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.34 mL 86.72 mL 173.43 mL
    0.5 mM 3.47 mL 17.34 mL 34.69 mL
    1 mM 1.73 mL 8.67 mL 17.34 mL
    5 mM 0.35 mL 1.73 mL 3.47 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.