Product Data Sheet
Bendamustine HCl (SDX-105)
Catalog No. A10124
Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.
| Catalog Num | A10124 |
|---|---|
| M. Wt | 394.7 |
| Formula | C16H21Cl2N3O2.HCl |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3543-75-7 |
| Synonyms | Ribomustin, Treanda, Treakisym |
| SMILES | CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| Discription | Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. |
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| Targets |
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| In vitro (25°C) | DMSO | 69 mg/mL (174.8 mM) | |
| Water | 2 mg/mL (5.06 mM) | ||
| Ethanol | 15 mg/mL (37.99 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.34 mL | 126.68 mL | 253.36 mL |
| 0.5 mM | 5.07 mL | 25.34 mL | 50.67 mL |
| 1 mM | 2.53 mL | 12.67 mL | 25.34 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
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Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
