Product Data Sheet

BI 2536

Catalog No. A10134

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BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
Adooq's BI 2536 has been cited by 10 publications
  • Nuria Gallisa-Sune, .et al. , Nat Commun, 2023, Apr 27;14(1):2434 PMID: 37105961
  • Kei K Ito, .et al. , J Cell Biol, 2021, Mar 1;220(3):e202005153 PMID: 33492359
  • Ryuzaburo Yuki, .et al. , J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
  • Yamagishi A, .et al. , Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
  • Bucko PJ, .et al. , Elife, 2019, Dec 24;8. pii: e52220 PMID: 31872801
  • Watanabe K, .et al. , Nat Commun, 2019, Feb 25;10(1):931 PMID: 30804344
  • Valérian Pasche, .et al. , Parasit Vectors, 2018, 11: 298 PMID: 29764454
  • Takeshi Wakida, .et al. , eLife, 2017, 6: e29953 PMID: 29254517
  • Majid Momeny, .et al. , Sci Rep, 2017, 7: 4204 PMID: 28646172
  • Ifuji A, .et al. , Exp Cell Res, 2017, Nov 15;360(2):347-357 PMID: 28942021
    • Chemical Information
    Catalog Num A10134
    M. Wt 521.7
    Formula C28H39N7O3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 755038-02-9
    Synonyms
    SMILES CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 21 mg/mL (40.25 mM)
    Water Insoluble
    Ethanol 98 mg/mL (187.86 mM)
    In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.17 mL 95.84 mL 191.68 mL
    0.5 mM 3.83 mL 19.17 mL 38.34 mL
    1 mM 1.92 mL 9.58 mL 19.17 mL
    5 mM 0.38 mL 1.92 mL 3.83 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.