Product Data Sheet

(E/Z)-BIBW2992 (E/Z-Afatinib)

Catalog No. A10141

main product photo
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
Adooq's (E/Z)-BIBW2992 (E/Z-Afatinib) has been cited by 6 publications
  • Song Han, .et al. , Neoplasia, 2025, Jan:59:101070 PMID: 39541736
  • Sang-Hyun Lee, .et al. , NPJ Precis Oncol, 2024, May 21;8(1):111 PMID: 38773241
  • Yi-Ru Pan, .et al. , Int J Biol Sci, 2023, May 21;19(9):2772-2786 PMID: 37324940
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Van Sebille YZ, .et al. , Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Chemical Information
    Catalog NumA10141
    M. Wt485.9
    FormulaC24H25ClFN5O3
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.439081-18-2
    SynonymsTomtovok
    SMILESCN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
    Biological Activity
    DescriptionBIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
    Targets
    TargetValue
    RETURN POLICY
    Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.