Product Data Sheet

Clozapine

Catalog No. A10236

main product photo
Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade.
Adooq's Clozapine has been cited by 5 publications
  • Madeleine S A Tan, .et al. , Mol Pharm, 2022, Sep 23 PMID: 36149013
  • Madeleine S. A. Tan, .et al. , Gels, 2022, Jan; 8(1): 38 PMID: 35049572
  • Milan D Valyear, .et al. , Nat Commun, 2020, Jul 28;11(1):3764 PMID: 32724058
  • Yutaro Kobayashi, .et al. , Transl Psychiatry, 2019, 9:181 PMID: 31371697
  • M.D. Valyear, .et al. , bioRxiv, 2018, 2018
    • Chemical Information
    Catalog Num A10236
    M. Wt 326.8
    Formula C18H19ClN4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 5786-21-0
    Synonyms Clozaril, Fazaclo, HF 1854, Iprox, Klozapol, Leponex
    SMILES CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade.
    Targets
    Target Value
    Solubility
    In vitro DMSO 59 mg/mL (180.52 mM)
    Water Insoluble
    Ethanol 29 mg/mL (88.73 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 30.6 mL 153 mL 306 mL
    0.5 mM 6.12 mL 30.6 mL 61.2 mL
    1 mM 3.06 mL 15.3 mL 30.6 mL
    5 mM 0.61 mL 3.06 mL 6.12 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.