Product Data Sheet

CP-690550 (Tofacitinib citrate)

Catalog No. A10241

main product photo
CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
Adooq's CP-690550 (Tofacitinib citrate) has been cited by 1 publications
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Chemical Information
    Catalog NumA10241
    M. Wt504.5
    FormulaC16H20N6O.C6H8O7
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.540737-29-9
    Synonyms
    SMILESC[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
    Biological Activity
    DescriptionCP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSOWarmed: 94 mg/mL (186.32 mM)
    WaterInsoluble
    EthanolInsoluble
    In vivo0.5% methylcellulose28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM19.82 mL99.11 mL198.22 mL
    0.5 mM3.96 mL19.82 mL39.64 mL
    1 mM1.98 mL9.91 mL19.82 mL
    5 mM0.4 mL1.98 mL3.96 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.