Product Data Sheet

Regorafenib (BAY 73-4506)

Catalog No. A10250

main product photo
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
Adooq's Regorafenib (BAY 73-4506) has been cited by 10 publications
  • Hasan U, .et al. , Research Square, 2023, 13 Apr
  • Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
  • Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Jindal A, .et al. , J Transl Sci, 2020, 7: 1-10
  • Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
  • Mariko Fujisawa, .et al. , Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
  • Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298
  • Sunil Kumar Yadava, .et al. , Colloids Surf B Biointerfaces, 2020, Mar 2;190:110927 PMID: 32169777
  • Takeshi Uenaka, .et al. , Hum Mol Genet, 2018, Nov 15; 27(22): 3974-3985 PMID: 30137437
  • Yi Xu, .et al. , Free Radic Biol Med, 2016, Jul; 96: 67-77 PMID: 27101738
    • Chemical Information
    Catalog Num A10250
    M. Wt 482.8
    Formula C21H15ClF4N4O3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 755037-03-7
    Synonyms
    SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 88 mg/mL (182.26 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.71 mL 103.56 mL 207.13 mL
    0.5 mM 4.14 mL 20.71 mL 41.43 mL
    1 mM 2.07 mL 10.36 mL 20.71 mL
    5 mM 0.41 mL 2.07 mL 4.14 mL
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    SHIPPING AND STORAGE
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