Product Data Sheet

Imatinib (Gleevec)

Catalog No. A10259

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Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
Adooq's Imatinib (Gleevec) has been cited by 6 publications
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Takafumi Shima, .et al. , Oncol Rep, 2022, 47: 7 PMID: 34738628
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
  • BM Duggan, .et al. , Endocrinology, 2020, May 30;bqaa086 PMID: 32473019
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
    • Chemical Information
    Catalog Num A10259
    M. Wt 493.6
    Formula C29H31N7O
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 152459-95-5
    Synonyms STI571, Glivec
    SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 28 mg/mL (56.72 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.26 mL 101.3 mL 202.59 mL
    0.5 mM 4.05 mL 20.26 mL 40.52 mL
    1 mM 2.03 mL 10.13 mL 20.26 mL
    5 mM 0.41 mL 2.03 mL 4.05 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.