Product Data Sheet

Danoprevir (RG7227)

Catalog No. A10284

main product photo
Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
Adooq's Danoprevir (RG7227) has been cited by 5 publications
  • Deqiang Kong, .et al. , Nat Commun, 2024, Jun 8;15(1):4894 PMID: 38849338
  • Xinyi Wang, .et al. , Nat Chem Biol, 2023, Oct 23 PMID: 37872400
  • Mahim Khan, .et al. , BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
  • Inês GARCEZ PALHA, .et al. , Biol Open, 2018, Nov 7 PMID: 30404898
  • Hui Shen, .et al. , PLoS One., 2013, 8(12): e82299 PMID: 24358168
  • Chemical Information
    Catalog NumA10284
    M. Wt731.8
    FormulaC35H46FN5O9S
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.850876-88-9
    SynonymsITMN-191, RO5190591
    SMILESCC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6
    Biological Activity
    DescriptionDanoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
    Targets
    TargetValue
    Solubility
    In vitro DMSO124 mg/mL (169.43 mM)
    WaterInsoluble
    Ethanol124 mg/mL (169.43 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM13.66 mL68.32 mL136.65 mL
    0.5 mM2.73 mL13.66 mL27.33 mL
    1 mM1.37 mL6.83 mL13.66 mL
    5 mM0.27 mL1.37 mL2.73 mL
    RETURN POLICY
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.