Product Data Sheet

Dexamethasone

Catalog No. A10299

main product photo
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
Adooq's Dexamethasone has been cited by 2 publications
  • Ken Kobayashi, .et al. , Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
    • Chemical Information
    Catalog Num A10299
    M. Wt 392.5
    Formula C22H29FO5
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 50-02-2
    Synonyms Decadron
    SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
    Solubility
    In vitro (25°C) DMSO 73 mg/mL (186 mM)
    Water Insoluble
    Ethanol 6 mg/mL (15.28 mM)
    In vivo 5% DMSO+45% PEG 300+H2O 12 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.48 mL 127.39 mL 254.78 mL
    0.5 mM 5.1 mL 25.48 mL 50.96 mL
    1 mM 2.55 mL 12.74 mL 25.48 mL
    5 mM 0.51 mL 2.55 mL 5.1 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.