Product Data Sheet

Everolimus (RAD001)

Catalog No. A10374

main product photo
Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
Adooq's Everolimus (RAD001) has been cited by 9 publications
  • Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763
  • Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
  • Gabriela Torres-Flores, .et al. , Adv Polym Technol, 2020, ID 5462949
  • Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580
  • BD Henriksbo, .et al. , Am J Physiol Endocrinol Metab, 2020, Jul 1;319(1):E110-E116 PMID: 32421368
  • Hiroshi Fukamachi, .et al. , J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995
  • Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Rieko Ohki, .et al. , Proc Natl Acad Sci U S A, 2014, 111(23): E2404-E2413 PMID: 24912192
    • Chemical Information
    Catalog Num A10374
    M. Wt 958.2
    Formula C53H83NO14
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 159351-69-6
    Synonyms SDZ-RAD, Certican, Zortress, Afinitor
    SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 91 mg/mL (94.97 mM)
    Water Insoluble
    Ethanol 6 mg/mL (6.26 mM)
    In vivo 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 10.44 mL 52.18 mL 104.36 mL
    0.5 mM 2.09 mL 10.44 mL 20.87 mL
    1 mM 1.04 mL 5.22 mL 10.44 mL
    5 mM 0.21 mL 1.04 mL 2.09 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.