Product Data Sheet

Fasudil HCl (HA-1077)

Catalog No. A10381

main product photo
Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
Adooq's Fasudil HCl (HA-1077) has been cited by 11 publications
  • Jiwan Choi, .et al. , Stem Cell Res Ther, 2024, Jul 29;15(1):229 PMID: 39075621
  • Patrick D Lyden, .et al. , Sci Transl Med, 2023, Sep 20;15(714):eadg8656 PMID: 37729432
  • Seongjun So, .et al. , Int J Mol Sci, 2022, Dec 31;24(1):701 PMID: 36614165
  • Chengyu Xiang, .et al. , J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
  • Yeonmi Lee, .et al. , Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
  • Jiwan Choi, .et al. , Stem Cell Res Ther, 2021, Nov 12;12(1):569
  • Jee Myung Yang, .et al. , Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
  • Jooyoung Lee, .et al. , Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
  • Kumar M, .et al. , Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
  • Wei J, .et al. , Shock, 2018, Dec;50(6):706-713 PMID: 29283979
  • Hofni A, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
  • Chemical Information
    Catalog NumA10381
    M. Wt327.8
    FormulaC14H17N3O2S.HCl
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.105628-07-7
    SynonymsAT-877
    SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
    Biological Activity
    DescriptionFasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO5 mg/mL (15.25 mM)
    Water60 mg/mL (183.02 mM)
    EthanolInsoluble
    In vivoSaline28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM30.51 mL152.53 mL305.06 mL
    0.5 mM6.1 mL30.51 mL61.01 mL
    1 mM3.05 mL15.25 mL30.51 mL
    5 mM0.61 mL3.05 mL6.1 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.