Product Data Sheet

FK-506 (Tacrolimus)

Catalog No. A10389

main product photo
FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Adooq's FK-506 (Tacrolimus) has been cited by 2 publications
  • Ogawa Y, .et al. , Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
  • Yuko Okamoto, .et al. , J Drug Deliv Sci Technol, 2018, 47: 62-66
    • Chemical Information
    Catalog Num A10389
    M. Wt 804
    Formula C44H69NO12
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 104987-11-3
    Synonyms Fujimycin, Prograf , Tacrolimus
    SMILES C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 81 mg/mL (100.74 mM)
    Water Insoluble
    Ethanol 71 mg/mL (88.31 mM)
    In vivo 5% DMSO+corn oil 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 12.44 mL 62.19 mL 124.38 mL
    0.5 mM 2.49 mL 12.44 mL 24.88 mL
    1 mM 1.24 mL 6.22 mL 12.44 mL
    5 mM 0.25 mL 1.24 mL 2.49 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.