Product Data Sheet

Imatinib Mesylate

Catalog No. A10468

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Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
Adooq's Imatinib Mesylate has been cited by 2 publications
  • Inge Govaerts, .et al. , J Hematol Oncol, 2021, 14: 97 PMID: 34167562
  • Genevra Kuziel, .et al. , Cancers (Basel), 2020, Jul 28;12(8):E2083 PMID: 32731354
    • Chemical Information
    Catalog Num A10468
    M. Wt 589.7
    Formula C29H31N7O.CH4SO3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 220127-57-1
    Synonyms Gleevec, Glivec, CGP-57148B, STI-571
    SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
    Targets
    Target Value
    Solubility
    In vitro DMSO 101 mg/mL (171.26 mM)
    Water 101 mg/mL (171.26 mM)
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.96 mL 84.79 mL 169.58 mL
    0.5 mM 3.39 mL 16.96 mL 33.92 mL
    1 mM 1.7 mL 8.48 mL 16.96 mL
    5 mM 0.34 mL 1.7 mL 3.39 mL
    RETURN POLICY
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.