Product Data Sheet

JNJ 26854165

Catalog No. A10491

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JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
Adooq's JNJ 26854165 has been cited by 1 publications
  • Chang SJ, .et al. , Arch Biochem Biophys, 2018, Jun 1;647:10-32 PMID: 29655550
  • Chemical Information
    Catalog Num A10491
    M. Wt 328.4
    Formula C21H20N4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 881202-45-5
    Synonyms JNJ26854165
    SMILES C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
    Solubility
    In vitro (25°C) DMSO 56 mg/mL (170.51 mM)
    Water Insoluble
    Ethanol 2 mg/mL (6.08 mM)
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 30.45 mL 152.25 mL 304.51 mL
    0.5 mM 6.09 mL 30.45 mL 60.9 mL
    1 mM 3.05 mL 15.23 mL 30.45 mL
    5 mM 0.61 mL 3.05 mL 6.09 mL
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    SHIPPING AND STORAGE
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