Product Data Sheet

KU-60019

Catalog No. A10507

main product photo
KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
Adooq's KU-60019 has been cited by 7 publications
  • Erika Nakatsuka, .et al. , Transl Oncol, 2024, Sep 12:50:102119 PMID: 39270525
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Yuri Tozaki, .et al. , Cancers (Basel), 2023, Jan 25;15(3):735 PMID: 36765693
  • Fu-Xing Gong, .et al. , Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
  • Hegedus C, .et al. , Cancers (Basel), 2019, Dec 18;12(1) PMID: 31861350
  • Masaya Igase, .et al. , Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
  • CHENGHUA LOU, .et al. , Oncol Lett, 2016, Jul; 12(1): 295-300 PMID: 27347141
  • Chemical Information
    Catalog NumA10507
    M. Wt547.7
    FormulaC30H33N3O5S
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.925701-49-1, 925701-46-8
    Synonyms
    SMILESC[C@@H]1CN(C[C@@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6
    Biological Activity
    DescriptionKU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
    Targets
    TargetValue
    Solubility
    In vitro DMSOWarmed: 18 mg/mL (32.86 mM)
    WaterInsoluble
    EthanolInsoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM18.26 mL91.29 mL182.58 mL
    0.5 mM3.65 mL18.26 mL36.52 mL
    1 mM1.83 mL9.13 mL18.26 mL
    5 mM0.37 mL1.83 mL3.65 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.