Product Data Sheet

LBH589 (Panobinostat)

Catalog No. A10518

main product photo
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
Adooq's LBH589 (Panobinostat) has been cited by 5 publications
  • Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Gils Jose, .et al. , Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
  • Shariful Islam, .et al. , Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
  • Giovanni Bocci, .et al. , ACS Pharmacol Transl Sci, 2020, Oct 14
  • Justin Kale, .et al. , EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135
    • Chemical Information
    Catalog Num A10518
    M. Wt 349.4
    Formula C21H23N3O2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 404950-80-7
    Synonyms NVP-LBH589
    SMILES CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 60 mg/mL (171.7 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+48% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.62 mL 143.1 mL 286.2 mL
    0.5 mM 5.72 mL 28.62 mL 57.24 mL
    1 mM 2.86 mL 14.31 mL 28.62 mL
    5 mM 0.57 mL 2.86 mL 5.72 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.