Product Data Sheet

MK-1775

Catalog No. A10599

main product photo
MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
Adooq's MK-1775 has been cited by 3 publications
  • Ting-Yu Chang, .et al. , Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
  • 2018, .et al. , FEBS Open Bio, 2018, Jun; 8(6): 1001-1012 PMID: 29928579
  • Rulina AV, .et al. , Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189
    • Chemical Information
    Catalog Num A10599
    M. Wt 500.6
    Formula C27H32N8O2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 955365-80-7
    Synonyms AZD1775
    SMILES CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 71 mg/mL (141.82 mM)
    Water Insoluble
    Ethanol 9 mg/mL (17.97 mM)
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.98 mL 99.88 mL 199.76 mL
    0.5 mM 4 mL 19.98 mL 39.95 mL
    1 mM 2 mL 9.99 mL 19.98 mL
    5 mM 0.4 mL 2 mL 4 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.