Product Data Sheet

AUY922 (Luminespib, NVP-AUY922)

Catalog No. A10659

main product photo
AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
Adooq's AUY922 (Luminespib, NVP-AUY922) has been cited by 2 publications
  • Haruka Wakasa, .et al. , J Mammary Gland Biol Neoplasia, 2022, Jun;27(2):155-170 PMID: 35581442
  • Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113
    • Chemical Information
    Catalog Num A10659
    M. Wt 465.5
    Formula C26H31N3O5
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 747412-49-3
    Synonyms VER-52296,
    SMILES CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Warmed: 86 mg/mL (184.72 mM)
    Water Insoluble
    Ethanol 29 mg/mL (62.28 mM)
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.48 mL 107.41 mL 214.82 mL
    0.5 mM 4.3 mL 21.48 mL 42.96 mL
    1 mM 2.15 mL 10.74 mL 21.48 mL
    5 mM 0.43 mL 2.15 mL 4.3 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.