Product Data Sheet

PD-0332991 HCl (Palbociclib HCl)

Catalog No. A10701

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PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Adooq's PD-0332991 HCl (Palbociclib HCl) has been cited by 4 publications
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Hiroki Ozawa, .et al. , Transl Oncol, 2022, Feb;16:101307 PMID: 34902741
  • Cong Li, .et al. , Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Pirita Pekkonen, .et al. , Cell Cycle, 2014, Dec 1; 13(23): 3670-3684 PMID: 25483078
  • Chemical Information
    Catalog NumA10701
    M. Wt484
    FormulaC24H29N7O2.HCl
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.827022-32-2
    Synonyms
    SMILESCC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
    Biological Activity
    DescriptionPD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSOWarmed: 3 mg/mL (6.19 mM)
    Water30 mg/mL (61.98 mM)
    EthanolInsoluble
    In vivoSaline5 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM20.66 mL103.31 mL206.61 mL
    0.5 mM4.13 mL20.66 mL41.32 mL
    1 mM2.07 mL10.33 mL20.66 mL
    5 mM0.41 mL2.07 mL4.13 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.