Product Data Sheet

Perifosine (NSC-639966)

Catalog No. A10709

main product photo
Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
Adooq's Perifosine (NSC-639966) has been cited by 4 publications
  • Bjune K, .et al. , PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
  • Kyoung-Jae Won, .et al. , Cell Death Dis, 2017, Jan; 8(1): e2554 PMID: 28079882
  • Zhipeng Li, .et al. , Oncotarget, 2016, May 31; 7(22): 31892-31906 PMID: 26895469
  • Won KJ, .et al. , Apoptosis., 2014, Jan;19(1):179-90 PMID: 24085402
    • Chemical Information
    Catalog Num A10709
    M. Wt 461.7
    Formula C25H52NO4P
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 157716-52-4
    Synonyms KRX-0401
    SMILES CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Insoluble
    Water 85 mg/mL (184.11mM)
    Ethanol 85 mg/mL (184.11mM)
    In vivo water 7 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.66 mL 108.3 mL 216.59 mL
    0.5 mM 4.33 mL 21.66 mL 43.32 mL
    1 mM 2.17 mL 10.83 mL 21.66 mL
    5 mM 0.43 mL 2.17 mL 4.33 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.