Product Data Sheet

PF-2341066 (Crizotinib)

Catalog No. A10712

main product photo
PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
Adooq's PF-2341066 (Crizotinib) has been cited by 6 publications
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
  • Yu B, .et al. , J Sep Sci, 2020, Jan 22 PMID: 31970927
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Saki Omote, .et al. , Sci Rep, 2018, 8: 9237 PMID: 29915248
  • Arakawa H, .et al. , J Pharm Sci, 2017, Sep;106(9):2899-2903 PMID: 28336299
    • Chemical Information
    Catalog Num A10712
    M. Wt 450.3
    Formula C21H22Cl2FN5O
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 877399-52-5
    Synonyms
    SMILES C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 8 mg/mL (17.76 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+30% PEG 300+dd H2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.21 mL 111.04 mL 222.07 mL
    0.5 mM 4.44 mL 22.21 mL 44.41 mL
    1 mM 2.22 mL 11.1 mL 22.21 mL
    5 mM 0.44 mL 2.22 mL 4.44 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.