Product Data Sheet

Rifabutin

Catalog No. A10790

main product photo
Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria.
Adooq's Rifabutin has been cited by 3 publications
  • Matt D Johansen, .et al. , Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
  • Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Dinah Binte Aziz, .et al. , Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540
  • Chemical Information
    Catalog Num A10790
    M. Wt 847
    Formula C46H62N4O11
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 72559-06-9
    Synonyms Mycobutin
    SMILES C[C@H]1/C=C/C=C(\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)/C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria.
    Solubility
    In vitro DMSO 59 mg/mL (69.65 mM)
    Water Insoluble
    Ethanol 39 mg/mL (46.04 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 11.81 mL 59.03 mL 118.06 mL
    0.5 mM 2.36 mL 11.81 mL 23.61 mL
    1 mM 1.18 mL 5.9 mL 11.81 mL
    5 mM 0.24 mL 1.18 mL 2.36 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.