Product Data Sheet

Telaprevir (VX-950)

Catalog No. A10902

main product photo
Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
Adooq's Telaprevir (VX-950) has been cited by 9 publications
  • Mahim Khan, .et al. , BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
  • Adita Ayu Permanasari, .et al. , BMC Complement Med Ther, 2021, Oct 12;21(1):260 PMID: 34641875
  • Che C Colpitts, .et al. , eLife, 2020, 9: e52237 PMID: 32539931
  • TS Wahyuni, .et al. , Southeast Asian J Trop Med public health, 2020, 51(1)
  • Stefan Bittmann, .et al. , J Regen Biol Med, 2020, 2(2):1-3
  • Wahyuni TS, .et al. , J Basic Clin Physiol Pharmacol, 2019, Dec 14 PMID: 31837259
  • Jacobs CL, .et al. , Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
  • Apriyanto DR, .et al. , Jpn J Infect Dis, 2016, May 20;69(3):213-20 PMID: 26255732
  • Mizuki Yamamoto, .et al. , Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352
    • Chemical Information
    Catalog Num A10902
    M. Wt 679.9
    Formula C36H53N7O6
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 402957-28-2
    Synonyms VX950, Incivek, Incivo
    SMILES CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 131 mg/mL (192.69 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 14.71 mL 73.54 mL 147.08 mL
    0.5 mM 2.94 mL 14.71 mL 29.42 mL
    1 mM 1.47 mL 7.35 mL 14.71 mL
    5 mM 0.29 mL 1.47 mL 2.94 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.