Product Data Sheet

Cis-Lomibuvir (cis-VX-222)

Catalog No. A10980

main product photo
VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
Adooq's Cis-Lomibuvir (cis-VX-222) has been cited by 2 publications
  • Wataru Ito, .et al. , Antivir Chem Chemother, 2015, Dec; 24(5-6): 148-154 PMID: 27503576
  • Hui Shen, .et al. , PLoS One., 2013, 8(12): e82299 PMID: 24358168
  • Chemical Information
    Catalog NumA10980
    M. Wt445.6
    FormulaC25H35NO4S
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.1026785-59-0
    SynonymsVCH222, VX222
    SMILESCC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
    Biological Activity
    DescriptionVX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO76 mg/mL (170.55 mM)
    WaterInsoluble
    Ethanol76 mg/mL (170.55 mM)
    In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM22.44 mL112.21 mL224.42 mL
    0.5 mM4.49 mL22.44 mL44.88 mL
    1 mM2.24 mL11.22 mL22.44 mL
    5 mM0.45 mL2.24 mL4.49 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.