Product Data Sheet

YM155 (Sepantronium Bromide)

Catalog No. A11002

main product photo
YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
Adooq's YM155 (Sepantronium Bromide) has been cited by 13 publications
  • Atieh Pourbagheri-Sigaroodi, .et al. , Iran J Allergy Asthma Immunol, 2024, 23(6):699-726
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Ali Nasrollahzadeh, .et al. , Biochim Biophys Acta Mol Cell Res, 2021, Jun 26;1868(10):119087 PMID: 34182011
  • Chia-Hui Huang, .et al. , Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
  • Turner TH, .et al. , Sci Rep, 2020, Jan 30;10(1):1493 PMID: 32001757
  • Chiou JT, .et al. , Toxicol Appl Pharmacol, 2019, Dec 16;387:114857 PMID: 31837377
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Momeny M, .et al. , Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
  • Yamamoto M, .et al. , Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
  • Vázquez-Mellado MJ, .et al. , Oncol Rep, 2018, Nov 27 PMID: 30483799
  • MASAHIRO YAMAMOTO, .et al. , Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
  • Ahn MR, .et al. , Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
  • MASAYA MINODA, .et al. , Int J Oncol, 2015, Sep; 47(3): 891-899 PMID: 26166250
  • Chemical Information
    Catalog NumA11002
    M. Wt443.3
    FormulaC20H19BrN4O3
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.781661-94-7
    Synonyms
    SMILESCC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
    Biological Activity
    DescriptionYM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO52 mg/mL (117.3 mM)
    Water85 mg/mL (191.75 mM)
    Ethanol6 mg/mL (13.53 mM)
    In vivoSaline28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM22.56 mL112.79 mL225.58 mL
    0.5 mM4.51 mL22.56 mL45.12 mL
    1 mM2.26 mL11.28 mL22.56 mL
    5 mM0.45 mL2.26 mL4.51 mL
    RETURN POLICY
    Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.