Product Data Sheet

BKM120 (NVP-BKM120, Buparlisib)

Catalog No. A11016

main product photo
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
Adooq's BKM120 (NVP-BKM120, Buparlisib) has been cited by 11 publications
  • Giri R. Gnawali, .et al. , Medicinal Chemistry Research, 2022, 31: 1154-1175
  • Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
  • Jeremiah J Bearss, .et al. , EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867
  • Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580
  • Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Jin H. Song, .et al. , Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Saijo A, .et al. , Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Pridham KJ, .et al. , Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Charles-André Philip, .et al. , BMC Cancer, 2017, 17: 638 PMID: 28886696
  • Rogers HA, .et al. , Clin Cancer Res., 2013, Dec 1;19(23):6450-60 PMID: 24077346
    • Chemical Information
    Catalog Num A11016
    M. Wt 410.4
    Formula C18H21F3N6O2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 944396-07-0
    Synonyms
    SMILES C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 76 mg/mL (185.18 mM)
    Water Insoluble
    Ethanol 2 mg/mL (4.87 mM)
    In vivo 5% DMSO+30% PEG 300+ddH2O 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.37 mL 121.83 mL 243.66 mL
    0.5 mM 4.87 mL 24.37 mL 48.73 mL
    1 mM 2.44 mL 12.18 mL 24.37 mL
    5 mM 0.49 mL 2.44 mL 4.87 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.