Product Data Sheet

PCI-32765 (Ibrutinib)

Catalog No. A11020

main product photo
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
Adooq's PCI-32765 (Ibrutinib) has been cited by 5 publications
  • Marta G Fuster, .et al. , Pharmaceutics, 2023, Apr 7;15(4):1186 PMID: 37111671
  • Simonowski A, .et al. , Biochim Biophys Acta Mol Cell Res, 2019, Dec 11;1867(4):118622 PMID: 31837347
  • Carolin N. Zorn, .et al. , Sci Rep, 2018, 8: 15467 PMID: 30341350
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
    • Chemical Information
    Catalog Num A11020
    M. Wt 440.5
    Formula C25H24N6O2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 936563-96-1
    Synonyms Ibrutinib
    SMILES C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 81 mg/mL (183.88 mM)
    Water Insoluble
    Ethanol 41 mg/mL (93.07 mM)
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.7 mL 113.51 mL 227.01 mL
    0.5 mM 4.54 mL 22.7 mL 45.4 mL
    1 mM 2.27 mL 11.35 mL 22.7 mL
    5 mM 0.45 mL 2.27 mL 4.54 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.