Product Data Sheet

CX-5461

Catalog No. A11065

main product photo
CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
Adooq's CX-5461 has been cited by 12 publications
  • Saruul Tungalag, .et al. , Int J Hematol, 2023, Feb 13 PMID: 36780110
  • Martine Chebrout, .et al. , J Cell Sci, 2022, 135 (6): jcs258798 PMID: 35048992
  • Taro Mannena, .et al. , Mol Biol Cell, 2021, 32:ar33, 1-11 PMID: 34495685
  • Shuichiro Okamoto, .et al. , Biosci Biotechnol Biochem, 2020, Aug 15;1-8 PMID: 32799625
  • Ahmed Abdullah Ahmed, .et al. , Sci Rep, 2020, 10: 12192 PMID: 32699225
  • Abed Saady, .et al. , Dyes Pigm, 2020, 174: 107986
  • Jackobel AJ, .et al. , Biochim Biophys Acta Gene Regul Mech, 2019, Aug 2:194408 PMID: 31382053
  • Hiroaki Suzuki, .et al. , Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
  • Anastasia Gelgor, .et al. , Oncotarget, 2018, Mar 2; 9(17): 13822-13833 PMID: 29568397
  • Wang ZF, .et al. , Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
  • Yuko Fujiwara, .et al. , EBioMedicine, 2018, Jul; 33: 33-48 PMID: 30049386
  • Maïmouna Coura Kone, .et al. , Biol Reprod, 2016, Apr;94(4):95, 1-12 PMID: 26984997
    • Chemical Information
    Catalog Num A11065
    M. Wt 513.6
    Formula C27H27N7O2S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1138549-36-6
    Synonyms CX5461
    SMILES CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
    Targets
    Target Value
    Solubility
    In vitro DMSO <1 mg/mL
    Water Insoluble
    Ethanol DMF: Warmed: 3 mg/mL (5.84 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.47 mL 97.35 mL 194.7 mL
    0.5 mM 3.89 mL 19.47 mL 38.94 mL
    1 mM 1.95 mL 9.74 mL 19.47 mL
    5 mM 0.39 mL 1.95 mL 3.89 mL
    RETURN POLICY
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.