Product Data Sheet

Canagliflozin

Catalog No. A11100

main product photo
Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
Adooq's Canagliflozin has been cited by 3 publications
  • Jing Zhou, .et al. , Exp Mol Med, 2022, Nov; 54(11): 2007-2021 PMID: 36385558
  • David Papadopoli, .et al. , Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
  • Angelopoulou A, .et al. , Nanomedicine, 2018, Oct;13(19):2435-2454 PMID: 30311542
    • Chemical Information
    Catalog Num A11100
    M. Wt 444.5
    Formula C24H25FO5S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 842133-18-0
    Synonyms
    SMILES CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 79 mg/mL (177.71 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 0.5% CMC+0.25% Tween 80 17 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.5 mL 112.49 mL 224.97 mL
    0.5 mM 4.5 mL 22.5 mL 44.99 mL
    1 mM 2.25 mL 11.25 mL 22.5 mL
    5 mM 0.45 mL 2.25 mL 4.5 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.