Product Data Sheet

Dinaciclib (SCH 727965)

Catalog No. A11129

main product photo
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
Adooq's Dinaciclib (SCH 727965) has been cited by 4 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Sepideh Izadi, .et al. , Pharm Res, 2020, Sep 17;37(10):196 PMID: 32944844
  • Shahin Hallaj, .et al. , Life Sci, 2020, Jul 26 PMID: 32726663
  • Washio I, .et al. , Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888
    • Chemical Information
    Catalog Num A11129
    M. Wt 396.5
    Formula C21H28N6O2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 779353-01-4
    Synonyms SCH727965, SCH-727965
    SMILES CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Warmed: 22 mg/mL (55.48 mM)
    Water Insoluble
    Ethanol Warmed: 7 mg/mL (17.65 mM)
    In vivo 2% DMSO+30% PEG 300+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.22 mL 126.1 mL 252.21 mL
    0.5 mM 5.04 mL 25.22 mL 50.44 mL
    1 mM 2.52 mL 12.61 mL 25.22 mL
    5 mM 0.5 mL 2.52 mL 5.04 mL
    RETURN POLICY
    Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.