Product Data Sheet

LY2109761

Catalog No. A11133

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LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
Adooq's LY2109761 has been cited by 5 publications
  • Yimei Wei, .et al. , Int J Rheum Dis, 2024, May;27(5):e15164 PMID: 38706209
  • Yan Yang, .et al. , J Thorac Dis, 2024, Feb 29;16(2):1128-1140 PMID: 38505034
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Uto T, .et al. , J Allergy Clin Immunol, 2018, Jun;141(6):2156-2167.e9 PMID: 29477579
  • Jared M. Fischer, .et al. , Proc Natl Acad Sci U S A, 2016, Oct 25; 113(43): 12192-12197 PMID: 27791005
  • Chemical Information
    Catalog NumA11133
    M. Wt441.5
    FormulaC26H27N5O2
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.700874-71-1
    SynonymsLY-2109761
    SMILESC1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
    Biological Activity
    DescriptionLY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
    Solubility
    In vitro (25°C) DMSO2 mg/mL (4.52 mM)
    WaterInsoluble
    EthanolInsoluble
    In vivo0.5% CMC+0.25% Tween 80 (suspensions)15 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM22.65 mL113.25 mL226.5 mL
    0.5 mM4.53 mL22.65 mL45.3 mL
    1 mM2.27 mL11.33 mL22.65 mL
    5 mM0.45 mL2.27 mL4.53 mL
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    SHIPPING AND STORAGE
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