Product Data Sheet

SCH 900776 (MK-8776)

Catalog No. A11167

main product photo

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Adooq's SCH 900776 (MK-8776) has been cited by 5 publications
  • Hong Yang, .et al. , Research Square, 2022, May 9th
  • Motofumi Suzuki, .et al. , Int J Radiat Oncol Biol Phys, 2021, May 25;S0360-3016(21)00361-8 PMID: 34112559
  • Min Wu, .et al. , Haematologica, 2019, 104 PMID: 30975911
  • Permata TBM, .et al. , Oncogene, 2019, Feb 12 PMID: 30755733
  • Hiro Sato, .et al. , Nat Commun, 2017, 8: 1751 PMID: 29170499
    • Chemical Information
    Catalog Num A11167
    M. Wt 376.25
    Formula C15H18BrN7
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 891494-63-6
    Synonyms SCH-900776, MK-8776, MK8776, MK 8776
    SMILES NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 3 mg/mL (7.97 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% propylene glycol 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.58 mL 132.89 mL 265.78 mL
    0.5 mM 5.32 mL 26.58 mL 53.16 mL
    1 mM 2.66 mL 13.29 mL 26.58 mL
    5 mM 0.53 mL 2.66 mL 5.32 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.