AZ 3146
Catalog No. A11170
AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.
Catalog Num | A11170 |
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M. Wt | 452.55 |
Formula | C24H32N6O3 |
Purity | >98% |
Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
CAS No. | 1124329-14-1 |
Synonyms | AZ-3146 |
SMILES | CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Discription | AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores. |
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Targets |
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In vitro | DMSO | 27 mg/mL (59.66 mM) | |
Water | Insoluble | ||
Ethanol | 87 mg/mL (192.24 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 22.1 mL | 110.49 mL | 220.97 mL |
0.5 mM | 4.42 mL | 22.1 mL | 44.19 mL |
1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
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