Product Data Sheet

LY-411575

Catalog No. A11176

main product photo

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Adooq's LY-411575 has been cited by 6 publications
  • Haiwen Yu, .et al. , Immunol Invest, 2023, Feb;52(2):241-255 PMID: 36562737
  • Wojciech J Szlachcic, .et al. , iScience, 2022, Jul 15;25(7) PMID: 35756892
  • Zhang ZH, .et al. , APMIS, 2019, Jul 5 PMID: 31274210
  • Bo Pang, .et al. , Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. , Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. , Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
    • Chemical Information
    Catalog Num A11176
    M. Wt 479.48
    Formula C26H23F2N3O4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 209984-57-6
    Synonyms LY411575
    SMILES C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 94 mg/mL (196.04 mM)
    Water Insoluble
    Ethanol 13 mg/mL (27.11 mM)
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.86 mL 104.28 mL 208.56 mL
    0.5 mM 4.17 mL 20.86 mL 41.71 mL
    1 mM 2.09 mL 10.43 mL 20.86 mL
    5 mM 0.42 mL 2.09 mL 4.17 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.