Product Data Sheet

LY-411575

Catalog No. A11176

main product photo

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Adooq's LY-411575 has been cited by 6 publications
  • Haiwen Yu, .et al. , Immunol Invest, 2023, Feb;52(2):241-255 PMID: 36562737
  • Wojciech J Szlachcic, .et al. , iScience, 2022, Jul 15;25(7) PMID: 35756892
  • Zhang ZH, .et al. , APMIS, 2019, Jul 5 PMID: 31274210
  • Bo Pang, .et al. , Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. , Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. , Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
  • Chemical Information
    Catalog NumA11176
    M. Wt479.48
    FormulaC26H23F2N3O4
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.209984-57-6
    SynonymsLY411575
    SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
    Biological Activity
    Description

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO94 mg/mL (196.04 mM)
    WaterInsoluble
    Ethanol13 mg/mL (27.11 mM)
    In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM20.86 mL104.28 mL208.56 mL
    0.5 mM4.17 mL20.86 mL41.71 mL
    1 mM2.09 mL10.43 mL20.86 mL
    5 mM0.42 mL2.09 mL4.17 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.