NSC-207895 (XI-006)
Catalog No. A11179
NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.
Catalog Num | A11179 |
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M. Wt | 279.25 |
Formula | C11H13N5O4 |
Purity | >98% |
Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
CAS No. | 58131-57-0 |
Synonyms | NSC207895 |
SMILES | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Discription | NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. |
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Targets |
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In vitro | DMSO | 0.39 mg/mL (1.39 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 35.81 mL | 179.05 mL | 358.1 mL |
0.5 mM | 7.16 mL | 35.81 mL | 71.62 mL |
1 mM | 3.58 mL | 17.91 mL | 35.81 mL |
5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
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